As I have shared before, if we are expecting to spend a few days in a place we usually opt for a vacation rental over a hotel.  It allows us to cut down on expenses by preparing our own food. (We usually do one nice dinner locally and prepare our other meals at 'home')  It also gives us a feel for how regular people in the area live and work every day.  In Prague it was an old walk-up townhouse just a half block from the Infant Jesus Shrine and close to the Charles Bridge.  A couple of the units were vacation rentals but the rest were full-time tenants.  We loved it. 

Quarters were spacious this time but sometimes they are less so.  And it goes without saying there will a lot more, um, togetherness in the car and in small vacation rental than at home.   Michelle Duggar discusses troubleshooting snug spaces and crankiness on the road here.